Ammonia → Morpholine-3-carboxamide
Reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([O:10]C)=O.[NH3:12]>CO>[NH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([NH2:12])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of methyl morpholine-3-carboxylate hydrochloride (0.55 g, 3.0 mmol) and a solution of NH3 in methanol (7 mol/L, 20 mL) was stirred at 50° C. for 24 hours in a sealed tube. The mixture was concentrated in vacuo to give the title compound as glutinous semisolid (0.39 g, 99%). The compound was characterized by the following spectroscopic data:
Workup
- concentrationThe mixture was concentrated in vacuo
Sources & evidence
- ORD record
- ord-13e5a44e7f7c4fccb815db4929082891
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09340538B2
Reaction notes
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