3-Morpholinecarboxylic acid → HCID 90043296, compound

HRID 524654

Reaction equation

HRID 524654 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20]Br)[NH:12][C:11]([C:22]2[S:23][CH:24]=[C:25]([CH2:27][C:28]([NH:30][CH:31]([CH3:33])[CH3:32])=[O:29])[N:26]=2)=[N:10]1.[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH:35]1[C:40]([OH:42])=[O:41]>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:10]=[C:11]([C:22]2[S:23][CH:24]=[C:25]([CH2:27][C:28]([NH:30][CH:31]([CH3:33])[CH3:32])=[O:29])[N:26]=2)[NH:12][C:13]([CH2:20][N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH:35]2[C:40]([OH:42])=[O:41])=[C:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

3

Reactant 2

HCID 33401523-Morpholinecarboxylic acidHCID 118107584Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-(isopropylamino)-2-oxo ethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Product 1

HCID 90043296HCID 90043296, compoundYield 49%

Procedure

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-(isopropylamino)-2-oxo ethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.2 g, 2 mmol) was reacted with morpholine-3-carboxylic acid (0.39 g, 3 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.64 g, 49%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-f6b7a4698184460fabee2b488644e3e9
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Linked notes

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