HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4,5-Trimethoxybenzaldehyde → 2,4-Diamino-6-[(3,4,5-trimethoxyphenylmethyl)imino]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4,5-Trimethoxybenzaldehyde | HCID 6858 | — |
| Reactant | 2,4,6-Triamino-5-chloroquinazoline | HCID 152217 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | 2,4-Diamino-6-[(3,4,5-trimethoxyphenylmethyl)imino]quinazoline | HCID 67571147 | — |
Reaction Steps
In a similar manner, 2,4,6-triamino-5-chloroquinazoline can be reacted with 3,4,5-trimethoxybenzaldehyde and hydrogen in the presence of Raney nickel in 2-ethoxyethanol, affording the corresponding 2,4-diamino-6-[(3,4,5-trimethoxyphenylmethyl)imino]quinazoline. Step C of Example 15 describes in detail the preparation of this compound. In a similar manner there may also be prepared 2,4-diamino-6-(substituted-aminomethyl)quinazolines.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616718 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-c08e66a8408a4e4eb012f3af00073397 |
| Source note | uspto-grants-1997_04 |