4-Chloro-1H-pyrrolo[2,3-b]pyridine → 4-(4,7-Diaza-spiro[2.5]oct-7-yl)-1H-pyrrolo[2,3-b]pyridine

Reaction equation

C(OC([N:8]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[CH:24]=[CH:23][NH:22][C:18]=3[N:19]=[CH:20]N=2)[CH2:12][C:9]21[CH2:11][CH2:10]2)=O)(C)(C)C.Cl[C:26]1C=CN=C2NC=CC=12.C(OC(N1CCNCC21CC2)=O)(C)(C)C>>[CH2:10]1[C:9]2([CH2:12][N:13]([C:16]3[CH:26]=[CH:20][N:19]=[C:18]4[NH:22][CH:23]=[CH:24][C:17]=34)[CH2:14][CH2:15][NH:8]2)[CH2:11]1

Participants

Reactant 3

HCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

HCID 51358567tert-Butyl 4,7-diazaspiro(2.5)octane-4-carboxylate

HCID 574772807-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl ester

Product 1

HCID 668983744-(4,7-Diaza-spiro[2.5]oct-7-yl)-1H-pyrrolo[2,3-b]pyridine

Procedure

Prepared in a sequence similar to the sequence described for intermediates 1 and 2, starting from 4-chloro-1H-pyrrolo[2,3-b]pyridine and 4,7-diaza-spiro[2.5]octane-4-carboxylic acid tert-butyl ester.

Workup

customPrepared in a sequence similar to the sequence

Sources & evidence

ORD record: ord-8ad067cb62f04fa6a4f187d77b47b28b
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09346809B2

Reaction notes

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