HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (chloroformyl)acetate → Ethyl thiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (chloroformyl)acetate | HCID 118030 | — |
| Reactant | Methanethioamide | HCID 3005587 | — |
| Product | Ethyl thiazole-5-carboxylate | HCID 459108 | 33% |
Reaction Steps
According to the procedure of Mashraqui and Keehn (J. Am. Chem. Soc. 1982, 104, 4461), ethyl α-chloro-α-formylacetate was condensed with thioformamide and vacuum distilled to provide 5.65 g (33%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616714 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-f3518c71ebc14df68b241e1171fe4697 |
| Source note | uspto-grants-1997_04 |