Mannitol → Furan-2,5-dione--methoxyethene (1/1)

HRID 529965

Reaction equation

S([O-])([O:4][CH2:5][CH2:6]CCCCCCCCCC)(=O)=[O:2].[Na+].[CH2:19](O)[C@H]([C@H:22]([C@@H:24]([C@@H:26]([CH2:28][OH:29])O)O)[OH:23])O>>[CH3:19][O:4][CH:5]=[CH2:6].[CH:24]1[C:22](=[O:23])[O:29][C:28](=[O:2])[CH:26]=1

Participants

Reactant 2

HCID 6251Mannitol

HCID 3423265Sodium Lauryl Sulfate

Product 1

HCID 62708Furan-2,5-dione--methoxyethene (1/1)

Procedure

For this purpose, 50 mL of GANTREZ® ES 425 ethanolic solution (50 mg/mL) were mixed with 100 mL of distilled water to form GANTREZ® ES nanoparticles. Different surfactants were added to the nanoparticles hydroalcoholic suspension such as sodium dodecyl sulfate (SDS) (100 mg), PLURONIC® F68 [ethylene oxide/propylene oxide block copolymer] (100 mg) or TWEEN® 80 [polyoxyethylene (20) sorbitan monooleate] (7.5 mg). Finally, 7.5 g of mannitol were added as excipient. To obtain a dry powder of the GANTREZ® ES nanoparticles, the suspension was dried in a Mini Spray-dryer Büchi B191 (Büchi Labortechnik AG, Switzerland) under the following conditions:

Sources & evidence

ORD record: ord-248c1c919d6a43458ef9bc4d631ff0c5
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09351940B2

Linked notes

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