Benzyl Alcohol → Phthalide

Reaction equation

[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][OH:10]>>[C:1]1([C:2]2[C:7](=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9][O:10]1)=[O:8]

Participants

Reactant 2

HCID 244Benzyl Alcohol

HCID 887Methanol

Product 1

HCID 6885Phthalide

Procedure

The procedure described in method F is repeated, except that the methanol is replaced by 50 ml of benzyl alcohol, affording a phthalide compound of the formula ##STR19## melting point 183°-184° C.

Sources & evidence

ORD record: ord-38a46896cfd64460abeefed1d758aed6
Source dataset: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05244860

Reaction notes

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