HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4,6-dimethoxypyrimidine-2-carboxylate → 4,6-Dimethoxypyrimidin-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4,6-dimethoxypyrimidine-2-carboxylate | HCID 4449183 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Product | 4,6-Dimethoxypyrimidin-2-carboxylic acid amide | HCID 58282682 | 100% |
Reaction Steps
Ethyl-4,6-dimethoxy-pyrimidin-2-carboxylate (25 g, 1 eq.) in NH3/MeOH (7 M, 15 mL) was irradiated in a microwave reactor at 100° C. for 15 min. The solution was concentrated in vacuo to yield compound 286 as a beige solid in 100% yield. MS (ESI, EI+): m/z=184 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353100B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-fecba534ef874545876118b99ec14c68 |
| Source note | uspto-grants-2016_05 |