Ethanol → 4,6-Dimethoxy-2-(4-trifluoromethyl-thiazol-2-yl)-pyrimidin-4-ol
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([C:11](=[S:13])[NH2:12])[N:4]=1.Br[CH2:15][C:16](=O)[C:17]([F:20])([F:19])[F:18].CC[OH:24]>>[CH3:10][O:9][C:7]1([OH:24])[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([C:11]2[S:13][CH:15]=[C:16]([C:17]([F:20])([F:19])[F:18])[N:12]=2)[NH:6]1Participants
4
Conditions
- Temperature
- 90 °C
Procedure
To a solution of compound 287 (14 g, 1 eq.) in EtOH (140 mL) was added 3-bromo-1,1,1-trifluoroacetone (8.8 mL, 1.2 eq.). The mixture was stirred at 90° C. for 16 hrs and concentrated in vacuo. DCM (20 mL) and water (20 mL) were added. Organics were dried over Na2SO4, filtered, concentrated under reduced pressure, and flushed on a silica gel column with 5% MeOH/DCM to yield compound 288 as a beige compound in 12% yield. MS (ESI, EI+): m/z=292 (MH+).