Phosphorus tribromide → 3-(Bromomethyl)pyrazolo[1,5-a]pyridine
Reaction equation
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[C:3]([CH2:10]O)[CH:2]=1.P(Br)(Br)[Br:13]>C(Cl)Cl>[Br:13][CH2:10][C:3]1[CH:2]=[N:1][N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To the solution of pyrazolo[1,5-a]pyridin-3-ylmethanol (2) (50 mg, 0.338 mmol) in DCM (2 mL) was added PBr3 (36.58 mg, 0.135 mmol) at room temperature for 30 min. The reaction solution was used in the next step.
Sources & evidence
- ORD record
- ord-11575ae34fdd45909ee7e4de3a874ed3
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09353104B2
Reaction notes
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