methyl 1-methyl-1H-pyrazole-3-carboxylate → 1-Methyl-1H-pyrazole-3-carboxamide
Reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]([O:9]C)=O)=[N:3]1.[NH3:11].O>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]([NH2:11])=[O:9])=[N:3]1Participants
3
Procedure
A solution of methyl 1-methyl-1H-pyrazole-3-carboxylate (1.1 g, 7.9 mmol) in NH3.H2O (10 mL) was stirred for 2 h at room temperature. The solvent was evaporated to give the crude product which was used for the next step without further purification.
Workup
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-c756c510a23a4298a52158dbfa1c4385
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09353104B2
Reaction notes
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