Ethyl diazoacetate → HCID 90419124, compound
Reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[CH2:12])=[N:3]1.[N+](=[CH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N-]>C1(C)C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[CH2:12][CH:15]2[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of compound 2 (1.1 g, 7 mmol) in toluene (5 mL) was treated with ethyl diazoacetate (1.2 g, 10 mmol) and stirred at reflux overnight under N2. The mixture was concentrated and the residue was purified by gradient elution on silica gel (PE: EA=5:1) to afford the title compound as a pale yellow oil.
Workup
- temperatureat reflux overnight under N2
- concentrationThe mixture was concentrated
- customthe residue was purified by gradient elution on silica gel (PE: EA=5:1)
Sources & evidence
- ORD record
- ord-6cd1060211504bde9583f4969f37471c
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09353104B2
Reaction notes
Loading…