Phosphorus tribromide → 5-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole
Reaction equation
[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8]O)[N:5]([CH3:10])[N:4]=1)[CH3:2].P(Br)(Br)[Br:12]>C(Cl)Cl>[Br:12][CH2:8][C:6]1[N:5]([CH3:10])[N:4]=[C:3]([CH2:1][CH3:2])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of compound 4 (500 mg, 3.57 mmol) in DCM (20 mL) was added PBr3 (386 mg, 1.43 mmol) was stirred at ° C. for 2 h. The mixture was washed with water, dried over Na2SO4. The solvent was evaporated to give the crude compound which was used in the next step without further purification.
Workup
- washThe mixture was washed with water
- dry with materialdried over Na2SO4
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-eada8e7c7393451a9f3883cce36f557a
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09353104B2
Reaction notes
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