2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine → 1,4'-Bipiperidine

HRID 53157

Reaction equation

HRID 53157 reaction equation
C(N(C1C2N=C([N:26]3[CH2:31][CH2:30][CH:29]([N:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[CH2:28][CH2:27]3)N=C(N3CCOCC3)C=2N=CN=1)C)C1C=CC=CC=1.ClC1N=C(N2CCOCC2)C2N=CN=C(N(CC3C=CC=CC=3)C)C=2N=1>>[N:32]1([CH:29]2[CH2:30][CH2:31][NH:26][CH2:27][CH2:28]2)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 128170202-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidineHCID 542067028-(N-benzyl-N-methyl-amino)-2-[4-(piperidino)-piperidin-1-yl]-4-morpholino-pyrimido [5,4-d]pyrimidine

Product 1

HCID 786071,4'-BipiperidineYield 54%

Procedure

8-(N-benzyl-N-methyl-amino)-2-[4-(piperidino)-piperidin-1-yl]-4-morpholino-pyrimido [5,4-d]pyrimidine From 2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine and 4-piperidino-piperidine Yield: 54% of theory, Melting point: 106° C. C28H38N8O (502.67)

Sources & evidence

ORD record
ord-6e6fbec6a1044fc9915fdf4a2e10cf88
Source dataset
uspto-grants-1997_04
Patent number
US05618814

Linked notes

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