2h-Pyrrolo[2,3-b]pyridin-2-one,5-acetyl-1,3-dihydro-1,3,3-trimethyl- → 1,3-dihydro-1-methyl-5-acetyl-2H-pyrrolo[2,3-b]pyridin-2-one

Reaction equation

[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=[C:5]2[C:4](C)(C)[C:3]1=[O:16].CN1C2=NC=C(Br)C=C2CC1=O>>[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=[C:5]2[CH2:4][C:3]1=[O:16]

Participants

Reactant 2

HCID 106088542h-Pyrrolo[2,3-b]pyridin-2-one,5-acetyl-1,3-dihydro-1,3,3-trimethyl-

HCID 152962685-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Product 1

HCID 108453511,3-dihydro-1-methyl-5-acetyl-2H-pyrrolo[2,3-b]pyridin-2-oneYield 84%

Procedure

By proceeding in the same manner as for the synthesis of the compound of Example 12, but replacing the 1,3-dihydro-1,3,3-trimethyl-5-bromo-2H-pyrrolo[2,3-b]pyridin-2-one with 1,3-dihydro-1-methyl-5-bromo-2H-pyrrolo[2,3-b]pyridin-2-one, the title compound is obtained in a yield of 84%. ##STR60##

Sources & evidence

ORD record: ord-ef37cb156e19453faa4d71aeba15b866
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05618819

Reaction notes

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