1-(2-Chloroethyl)pyrrolidine → HCID 178454409, compound

HRID 532041

Reaction equation

HRID 532041 reaction equation
[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]([C@H:24]2[CH2:29][CH2:28][C@H:27]([CH3:30])[CH2:26][CH2:25]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21]C#N)=[CH:19][N:20]=2)=[O:14])[CH2:8][CH2:7]1)(=[O:5])[CH2:2][CH2:3][CH3:4].SC[C@@H]([C@@H](CS)O)O.Cl[CH2:40][CH2:41][N:42]1[CH2:46][CH2:45][CH2:44][CH2:43]1>>[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]([C@H:24]2[CH2:29][CH2:28][C@H:27]([CH3:30])[CH2:26][CH2:25]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21][CH2:40][CH2:41][N:42]3[CH2:46][CH2:45][CH2:44][CH2:43]3)=[CH:19][N:20]=2)=[O:14])[CH2:8][CH2:7]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 439352DithioerythritolHCID 178454413HCID 178454413, compound

Product 1

HCID 178454409HCID 178454409, compound

Procedure

Prepared as described in general procedures (H) and (I) using 1-(1-butyryl-piperidin-4-yl)-1-(trans-4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and N-(2-chloroethyl)pyrrolidine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f9c9bcbd60bc48f98caa9e535e419da6
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Linked notes

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