Water → (1R,2S)-(+)-cis-1-Amino-2-indanol
Reaction equation
[C@@H:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10].S(=O)(=O)(O)O.O.C(#[N:20])C>>[NH2:20][C@@H:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10]Participants
5
Conditions
- Temperature
- -40 °C
Procedure
Cis-1,2-indandiol (1.0 g) was dissolved in acetonitrile (20 mL). cooled to -40° C. and fuming sulfuric acid (21% SO3, 0.8 mL) was added. The mixture was aged for 1 hour with gradual warming to 0° C. Water was added and the mixture heated to 80° C. for 1 hour to provide an aqueous solution of cis-1-amino-2-indanol.
Workup
- temperaturewith gradual warming to 0° C
- temperaturethe mixture heated to 80° C. for 1 hour
Sources & evidence
- ORD record
- ord-0067e158893844c9995a9aba06ba8064
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05618937
Reaction notes
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