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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 5339Generated: October 23, 2026

4-Bromophenol → Phenol, 4-(3-pyridinyl)-

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Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromophenolHCID 7808—
Reactant3-(Tributylstannyl)pyridineHCID 3483848—
CatalystHCID 178418476HCID 178418476—
Solvent1,4-DioxaneHCID 31275—
ProductPhenol, 4-(3-pyridinyl)-HCID 15304060%

Reaction Steps

26.8 g of 4-bromophenol was taken under protective gas in 1000 ml of dioxane, mixed with 90 g 3-tributylstannylpyridine [preparation according to litt.: Org. Magn. Resonance, 7 (1975), 610] and 11.1 g of bis-(triphenylphosphine)-palladium(II) chloride and refluxed for 15 hours. After concentration by evaporation in a vacuum and purification on silica gel, 15.92 g of the above compound is isolated.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05244886
Source datasetuspto-grants-1993_09
ORD IDord-7844a06e09664a17934167953fba756b
Source noteuspto-grants-1993_09