Cyclopropanemethanol → 5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5](F)=[N:6][CH:7]=1.[CH:10]1([CH2:13][OH:14])[CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([O:14][CH2:13][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1

Participants

Reactant 2

HCID 75644Cyclopropanemethanol

HCID 145496545-Bromo-2,3-difluoropyridine

Product 1

HCID 867151175-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine

Procedure

Following Typical Procedure 6, reaction of 5-bromo-2,3-difluoro-pyridine with cyclopropyl-methanol provided the subtitle compound. MS ESI+: m/z=246 [M+H]+.

Sources & evidence

ORD record: ord-667d431be3df480485687dff0fefd7da
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853412B2

Reaction notes

Loading…