2-(Oxolan-3-yl)acetic acid → N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(tetrahydrofuran-3-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(Oxolan-3-yl)acetic acid	HCID 4244905	—
Reactant	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
Product	N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(tetrahydrofuran-3-yl)acetamide	HCID 70975906	—

Reaction Steps

The product from Example 1B and 2-(tetrahydrofuran-3-yl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 8.44-8.46 (m, 1H), 8.27-8.29 (bs, 1H), 7.89-7.94 (m, 1H), 7.80-7.86 (m, 1H), 7.74-7.79 (m, 1H), 3.91-3.98 (m, 6H), 3.70-3.82 (m, 1H), 3.57-3.61 (m, 1H), 3.21-3.23 (m, 4H), 2.77-2.81 (m, 1H), 2.51-2.54 (m, 2H), 2.15-2.30 (m, 1H), 1.68-1.78 (m, 1H); MS (APCI+) M/Z 359 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08859549B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-a61851261451479eac7b85b0c7f4ec09
Source note	uspto-grants-2014_10