2-(2,4-Dimethoxyphenyl)acetic acid → 2-(2,4-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(2,4-Dimethoxyphenyl)acetic acid	HCID 350555	—
Reactant	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
Product	2-(2,4-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 70976016	—

Reaction Steps

The product of Example 1B and 2-(2,4-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (d, J=7.8 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.00 (m, 1H), 7.89-7.92 (m, 1H), 7.22 (d, J=8.2 Hz, 1H), 6.56 (d, J=2.4 Hz, 1H), 6.51 (dd, J=8.2, 2.4 Hz, 1H), 3.82-3.84 (m, 4H), 3.80 (s, 3H), 3.76 (s, 3H), 3.53 (s, 2H), 3.06-3.14 (m, 4H); MS (ESI+) M/Z 425 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08859549B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-30f670d105ac49339d24f7d1f71a0eca
Source note	uspto-grants-2014_10