Sodium borohydride → 2-(4-Chloro-3-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzonitrile
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:19]([F:22])([F:21])[F:20].[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:19]([F:20])([F:21])[F:22]Participants
4
Procedure
To a solution of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-formylbenzonitrile (5.0 g, 15.4 mmol) in methanol (50 mL) was added sodium borohydride (0.61 g, 16.1 mmol) at 0° C. The reaction mixture was stirred at rt for 30 min and concentrated. Purification via ISCO system (CH2Cl2/MeOH-20/1) afforded the title product (4.76 g) as an off-white solid. LC-MS (ESI): m/z 328 [M+H]+; 3.96 min (ret time).