Cyanogen Bromide → CID 67338391

Reaction equation

[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:7]=1[NH2:8].[N:15]#[C:16][Br:17]>>[BrH:17].[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:6]2[C:2]3[N:3]([CH2:4][CH2:5][N:1]=3)[C:16]([NH2:15])=[N:8][C:7]=2[CH:9]=1

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 583773892-(4,5-dihydro-1H-imidazol-2-yl)-5-methoxyaniline

Product 1

HCID 178419595CID 67338391

Procedure

The procedure used for the preparation of Intermediate C, Step 4 was used to prepare the title compound from 2-(4,5-dihydro-1H-imidazol-2-yl)-5-methoxyaniline (Step 2) and cyanogen bromide as a yellow solid (7.1 g, 56%). HPLC MS RT=1.07 min, [M-HBr+H]+=217.2

Sources & evidence

ORD record: ord-19a696ce108f464e8652bba74a434822
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859572B2

Reaction notes

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