HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 4-Mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide | HCID 178418292 | — |
| Product | 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one | HCID 23287882 | 60.8% |
Reaction Steps
Using the procedure of Example 20, 2.0 g (5.81 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide were treated with 1.47 g (5.81 mmol) of iodine to give 1.21 g of the title compound after recrystallization from isopropanol, mp 163°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620997 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-936364b3dca5411eb29bb3f0e11f8fa7 |
| Source note | uspto-grants-1997_04 |