2-Iodobenzylic alcohol → 2-Iodobenzaldehyde

HRID 537387

Reaction equation

HRID 537387 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 1

HCID 1076292-Iodobenzylic alcohol

Product 1

HCID 6434392-IodobenzaldehydeYield 91%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a flask, 2-iodobenzyl alcohol (4 g, 17.09 mmol) was dissolved in dichloromethane (MC, 85 ml), and then, manganese oxide (MnO2, 14.86 g, 170.92 mmol) was added thereto. The obtained reaction product was stirred under the reflux condition. When the reaction was completed, the obtained reaction product was cooled to the room temperature, and then, fiteated and concentrated using celite, to obtain the title compound (3.6 g, yield 91%).

Workup

  1. customThe obtained reaction product
  2. customthe obtained reaction product
  3. concentrationfiteated and concentrated

Sources & evidence

ORD record
ord-49e4f99a721a493cbbfd323ffbd7ab02
Source dataset
uspto-grants-2014_10
Patent number
US08859817B2

Linked notes

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