1-Bromo-2-iodobenzene → Tert-butyl{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate
Reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[Br:8].[C:9]([O:13][C:14](=[O:35])[NH:15][CH:16]([C:26]([N:28]1[CH2:33][CH2:32][CH:31]([CH3:34])[CH2:30][CH2:29]1)=[O:27])[CH2:17][CH2:18]C1C=CC=CC=1Cl)([CH3:12])([CH3:11])[CH3:10]>>[C:9]([O:13][C:14](=[O:35])[NH:15][CH:16]([C:26]([N:28]1[CH2:33][CH2:32][CH:31]([CH3:34])[CH2:30][CH2:29]1)=[O:27])[CH2:17][CH2:18][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[Br:8])([CH3:10])([CH3:11])[CH3:12]Participants
3
Procedure
tert-Butyl{3-(2-bromophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate is prepared from 2-iodobromobenzene in the same manner that tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate is synthesized.
Workup
- customis synthesized