2-Methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid → US10112934, Example 2
Reaction equation
[CH3:1][C:2]([S:7]([CH2:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(=[O:9])=[O:8])([CH3:6])[C:3]([OH:5])=O.[NH2:17][C:18]1[O:22][N:21]=[C:20]([C:23]([CH3:27])([CH3:26])[C:24]#[N:25])[CH:19]=1>>[C:24]([C:23]([CH3:27])([CH3:26])[C:20]1[CH:19]=[C:18]([NH:17][C:3](=[O:5])[C:2]([CH3:1])([S:7]([CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:9])=[O:8])[CH3:6])[O:22][N:21]=1)#[N:25]Participants
3
Procedure
Prepared according to procedure of example 1 starting from 100 mg (0.40 mmol) of 2-methyl-2-(tetrahydro-pyran-4-ylmethanesulfonyl)-propionic acid (intermediate 2) and 66.4 mg (0.44 mmol) 2-(5-amino-isoxazol-3-yl)-2-methyl-propionitrile (intermediate 7).
Workup
- customPrepared