Acetic Acid → N-Benzylacetamide

HRID 538954

Reaction equation

HRID 538954 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9](O)(=[O:11])[CH3:10]>>[C:9]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 7504Benzylamine

Product 1

HCID 11500N-Benzylacetamide

Conditions

Temperature
115 °C

Procedure

Benzylamine (1 mL) and acetic acid (20 mL) may be mixed together. The mixture may be heated at 115° C. for 17 hours. The excess acetic acid may be distilled from the reaction mixture using a rotary evaporator. The product may be crystallized from toluene. The mixture may be cooled to 0° C. and then filtered.

Workup

  1. distillationThe excess acetic acid may be distilled from the reaction mixture
  2. customa rotary evaporator
  3. customThe product may be crystallized from toluene
  4. temperatureThe mixture may be cooled to 0° C.
  5. filtrationfiltered

Sources & evidence

ORD record
ord-27a2c44870504edb8d0db479262b468b
Source dataset
uspto-grants-2014_10
Patent number
US08865920B2

Linked notes

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