Methyl L-prolinate → (S)-1-(2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

HRID 539501

Reaction equation

HRID 539501 reaction equation
[NH:1]1[CH2:9][CH2:8][CH2:7][C@H:2]1[C:3]([O:5][CH3:6])=[O:4].C(N[S:14]([C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[O:27])(=[O:16])=[O:15])CC>>[CH3:6][O:5][C:3]([C@@H:2]1[CH2:7][CH2:8][CH2:9][N:1]1[S:14]([C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[O:27])(=[O:15])=[O:16])=[O:4]

Participants

3

Reactant 2

HCID 853477Methyl L-prolinateHCID 112771782,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid propylamide

Product 1

HCID 9840785(S)-1-(2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Procedure

The title compound was prepared from L-Pro-OMe following the procedure for 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid propylamide.

Sources & evidence

ORD record
ord-b1b17ea0e8654bc9bdfdbd4830e897b7
Source dataset
uspto-grants-2014_10
Patent number
US08871718B2

Linked notes

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