D-Psicose → HCID 15729401, compound

HRID 539984

Reaction equation

HRID 539984 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([NH:14][C:15](=[O:17])[CH3:16])([CH3:13])[CH2:9]1)C1C=CC=CC=1.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O.[H][H]>[Pd].C(O)C>[CH3:13][C:10]1([NH:14][C:15](=[O:17])[CH3:16])[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

6

Reactant 3

HCID 441036D-PsicoseHCID 13787481N-(1-benzyl-3-methylpyrrolidin-3-yl)acetamideHCID 178418361HCID 178418361, compound

Product 1

HCID 15729401HCID 15729401, compoundYield 54.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N-(1-benzyl-3-methylpyrrolidin-3-yl)-acetamide (600 mg, 2.6 mmol), palladium on carbon (400 mg, 10%) and ethanol (20 mL) was stirred at 40° C. under 50 Psi of hydrogen for 16 hours. The resulting mixture was filtrated. The filtrate was concentrated in vacuo to give 200 mg of the desired product (yield was 54%), which was used for next step without any purification.

Workup

  1. filtrationThe resulting mixture was filtrated
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-91f6fca731ee4262b602bf3a77340fe9
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Linked notes

Loading…