tert-Butanol → CGP-47292 methyl ester
Reaction equation
[N:1]([CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[F:12])=[N+:2]=[N-:3].Br[C:14](=[CH2:19])[C:15]([O:17][CH3:18])=[O:16].C(O)(C)(C)C>O>[F:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][N:1]1[CH:19]=[C:14]([C:15]([O:17][CH3:18])=[O:16])[N:3]=[N:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In a preferred embodiment 2-(azidomethyl)-1,3- difluorobenzene is treated with methyl 2-bromoacrylate in mixture of t-butanol and water to produce methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate.
Sources & evidence
- ORD record
- ord-80c10a116cdf47a78f5ea984ecd04386
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08871945B2
Reaction notes
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