Ammonia → N-(3-Chloropropyl)dibutylamine

HRID 541096

Reaction equation

HRID 541096 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:7][CH2:8][CH2:9][CH3:10].N>>[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22595053N-Butyl-N-(3-chloropropyl)butan-1-amine--hydrogen chloride (1/1)

Product 1

HCID 96084N-(3-Chloropropyl)dibutylamine

Procedure

18.6 g of 68.4% 1-chloro-3-(di-n-butylamino)-propane hydrochloride (52.6 mmol) are placed in an equipped reactor and then 9.97 g of a 20% aqueous ammonia solution (56.9 mmol) are added at 20° C. The mixture is stirred for 15 minutes, and then the phases are decanted off and separated: the bottom phase consists of 1-chloro-3-(di-n-butylamino)-propane in the form of a free base. This phase is washed with 10 ml of water and 9.99 g of 1-chloro-3-(di-n-butylamino)-propane are thus isolated.

Workup

  1. customthe phases are decanted off
  2. customseparated
  3. washThis phase is washed with 10 ml of water and 9.99 g of 1-chloro-3-(di-n-butylamino)-propane
  4. customare thus isolated

Sources & evidence

ORD record
ord-1dd0129deb514f2fb01b0b8780a614c3
Source dataset
uspto-grants-2014_10
Patent number
US08871956B2

Linked notes

Loading…