4-Chloro-2-methylbenzoic acid → 4-Chloro-5-iodo-2-methylbenzoic acid

Reaction equation

[I:1][C:2]1[C:3](C)=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[Cl:13]C1C=CC(C(O)=O)=C(C)C=1>>[Cl:13][C:3]1[C:2]([I:1])=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([CH3:11])[CH:4]=1

Participants

Reactant 2

HCID 3482694-Chloro-2-methylbenzoic acid

HCID 230918755-Iodo-2,4-dimethylbenzoic acid

Product 1

HCID 682889484-Chloro-5-iodo-2-methylbenzoic acid

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 2.1, except 4-chloro-2-methylbenzoic acid was used in place of 2,4-dimethylbenzoic acid.

Sources & evidence

ORD record: ord-4e250ed55bef4c289ad2e1408c9e734b
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871790B2

Reaction notes

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