1-Carbomethoxy-4-benzylpiperazine → Methyl piperazine-1-carboxylate
Reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2].[H][H]>C(O)C.[Pd]>[C:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
34.0 g (0.15 mole) of 1-carbomethoxy-4-benzylpiperazine dissolved in 300 ml of ethanol was treated with hydrogen over a palladium catalyst at 40 psi and room-temperature for 24 hours. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was distilled, b.p. 70°-75° C. at 1.5 mmHg to give 16.0 g of 1-carbomethoxypiperazine.
Workup
- customThe catalyst was removed by filtration
- customthe solvent removed under reduced pressure
- distillationThe residue was distilled
Sources & evidence
- ORD record
- ord-15e9a2f423724c79a6999dbee1549894
- Source dataset
- uspto-grants-1987_04
- Patent number
- US04656175
Reaction notes
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