Ethylenediamine → Clonidine
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1S(O)(=O)=O.[CH2:13]([NH2:16])[CH2:14][NH2:15].[C:17](#[N:19])C>>[CH:6]1[CH:7]=[C:2]([Cl:1])[C:3]([NH:19][C:17]2[NH:16][CH2:13][CH2:14][N:15]=2)=[C:4]([Cl:8])[CH:5]=1Participants
4
Conditions
- Temperature
- 65 °C
Procedure
2,6-dichlorophenylsulfonic acid (1.0 g, 0.0037 m) was added to ethylenediamine (0.5 g, 0.008 m) in the absence of solvent. The reaction exothermed to 35° C. and was diluted with acetonitrile and heated at 65° C. for 7.25 hr. The reaction was concentrated, treated with sodium hydroxide and extracted with methylene chloride. The organic phase was dried and concentrated to yield 0.5 g of clonidine. The product was identified by spectroscopic methods.