2,3,5-Trimethylphenol → 2,3,5-Trimethylphenyl isopropyl ether

HRID 542343

Reaction equation

HRID 542343 reaction equation
[Cl-].[CH:2]([O:5][C:6]1[CH:31]=[C:30]([CH3:32])[C:9](C[P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[C:8]([CH3:33])[C:7]=1[CH3:34])([CH3:4])[CH3:3].CC1C(C)=CC(C)=CC=1O>>[CH:2]([O:5][C:6]1[CH:31]=[C:30]([CH3:32])[CH:9]=[C:8]([CH3:33])[C:7]=1[CH3:34])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 127692,3,5-TrimethylphenolHCID 867359034-Isopropoxy-2,3,6-trimethyl-benzyl-triphenylphosphonium chloride

Product 1

HCID 202100012,3,5-Trimethylphenyl isopropyl ether

Procedure

The 4-isopropoxy-2,3,6-trimethyl-benzyl-triphenylphosphonium chloride employed as the starting material is prepared by the procedure described in Example 18 by alkylation of 2,3,5-trimethylphenol to give 2,3,5-trimethylphenyl isopropyl ether (boiling point 115° C./11 mmHg), by haloformylation of the ether obtained to give 4-isopropoxy-2,3,6-trimethyl-benzyl chloride (nD20 =1.5433) and by reaction of the latter compound with triphenylphosphine.

Workup

  1. customis prepared by the procedure

Sources & evidence

ORD record
ord-3caabf0264504749a3fcdbf338d1f2a0
Source dataset
uspto-grants-1987_04
Patent number
US04656310

Linked notes

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