3-Difluoromethoxy-2-nitrotoluene → 2-(Difluoromethoxy)-6-methylaniline
Reaction equation
[F:1][CH:2]([F:14])[O:3][C:4]1[C:5]([N+:11]([O-])=O)=[C:6]([CH3:10])[CH:7]=[CH:8][CH:9]=1>C(O)C>[F:1][CH:2]([F:14])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:5]=1[NH2:11]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The procedures of Example 2 were repeated except that the starting material was 16.0 g (79 mmol) of 3-difluoromethoxy-2-nitrotoluene as dissolved in 100 ml of ethanol. As a result, 13.0 g of 2-difluoromethoxy-6-methyl aniline was obtained.
Sources & evidence
- ORD record
- ord-d9c6221693334c679788aeadd6e9a575
- Source dataset
- uspto-grants-1987_04
- Patent number
- US04659365
Reaction notes
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