Methanol → HCID 13084130, compound

HRID 543048

Reaction equation

HRID 543048 reaction equation
[CH3:1]O.S(Cl)(Cl)=O.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:19]([CH3:20])=[CH:18][C:17](=[O:21])[C:16]([C:22]([OH:24])=[O:23])=[N:15]2)=[CH:10][CH:9]=1>O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:19]([CH3:20])=[CH:18][C:17](=[O:21])[C:16]([C:22]([O:24][CH3:1])=[O:23])=[N:15]2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 197225Fenridazon

Product 1

HCID 13084130HCID 13084130, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 100 ml of methanol, cooled to -5° C., there is added dropwise 11.9 g (0.1 mol) of thionyl chloride. Upon completion of the addition 13.23 g (0.05 mol) of 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylic Acid (see Example 12) is added. The suspension formed is vacuum filtered after stirring at room temperature for 3 hrs. to afford the product, mp 183°-193° C. decomp. Treatment of the product with water affords the Methyl 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylate.

Workup

  1. additionis added
  2. customThe suspension formed
  3. filtrationfiltered
  4. customto afford the product, mp 183°-193° C. decomp

Sources & evidence

ORD record
ord-59c945fce7a74f389e3a98ca481f5395
Source dataset
uspto-grants-1987_04
Patent number
US04661145

Linked notes

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