Bromine → HCID 53827787, compound

HRID 543584

Reaction equation

HRID 543584 reaction equation
[Br:1]Br.[C:3]([C:5]1[CH:6]=[C:7]([CH:9]=[CH:10][C:11]=1[C:12]#[N:13])[NH2:8])#[N:4].C([O-])(=O)C.[Na+]>C(O)(=O)C>[Br:1][NH:8][C:7]1[CH:9]=[CH:10][C:11]([C:12]#[N:13])=[C:5]([C:3]#[N:4])[CH:6]=1

Participants

5

Reactant 3

HCID 24408Bromine2×HCID 925291,2-Benzenedicarbonitrile, 4-amino-HCID 517045Sodium Acetate

Product 1

HCID 53827787HCID 53827787, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of 6.7 g of bromine in 5 ml of acetic acid is slowly added dropwise at room temperature to a mixture of 5.7 g of 3,4-dicyanoaniline, 3.6 g of sodium acetate and 25 ml of acetic acid. When the addition of bromine is complete, the mixture is further stirred at room temperature until no more educt can be detected in a thin-layer chromatogram. The acetic acid is then removed in vacuo in a rotary evaporator. The residue is taken up in warm water and the product is isolated by filtration. The filter cake is washed well with water and dried in vacuo at 70° C., affording bromo-3,4-dicyanoaniline as a grey product which dissolves in dimethyl formamide to give an almost colourless solution. A thin-layer chromatogram shows the product to be a mixture of isomers. Rf values of the two main products: 0.43 and 0.55 respectively [determined on ready prepared silica gel plates 6 OF-254, MERCK Darmstadt; eluant:toluene/ethanol (4:1)].

Workup

  1. customThe acetic acid is then removed in vacuo in a rotary evaporator
  2. customthe product is isolated by filtration
  3. washThe filter cake is washed well with water
  4. customdried in vacuo at 70° C.

Sources & evidence

ORD record
ord-a3757bb3fd8449c3a907b49d0e897406
Source dataset
uspto-grants-1984_05
Patent number
US04447358

Linked notes

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