Kanamycin → Amikacin

HRID 543865

Reaction equation

HRID 543865 reaction equation
[CH2:1]1[C@@H:6]([NH:7][C:8]([C@@H:10]([OH:14])[CH2:11][CH2:12][NH2:13])=[O:9])[C@H:5]([O:15][C@H:16]2[O:21][C@H:20]([CH2:22][OH:23])[C@@H:19]([OH:24])[C@H:18]([NH2:25])[C@H:17]2[OH:26])[C@@H:4]([OH:27])[C@H:3]([O:28][C@H:29]2[O:34][C@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]2[OH:39])[C@H:2]1[NH2:40].OS(O)(=O)=O.C1[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](N)[C@H]2O)[C@@H]1N>O>[CH2:1]1[C@@H:6]([NH:7][C:8]([C@@H:10]([OH:14])[CH2:11][CH2:12][NH2:13])=[O:9])[C@H:5]([O:15][C@H:16]2[O:21][C@H:20]([CH2:22][OH:23])[C@@H:19]([OH:24])[C@H:18]([NH2:25])[C@H:17]2[OH:26])[C@@H:4]([OH:27])[C@H:3]([O:28][C@H:29]2[O:34][C@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]2[OH:39])[C@H:2]1[NH2:40]

Participants

4

Reactant 2

HCID 6032KanamycinHCID 5458175Amikacin Sulfate Salt

Product 1

HCID 37768Amikacin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Amikacin sulfate is a water-soluble, broad spectrum, semisynthetic aminoglycoside antibiotic derived from kanamycin, which is obtained from Streptomyces kanamyceticus. In normal adults, average peak serum concentrations of about 12, 16 and 21 μg/ml are obtained about 1 hour after intramuscular administration of 3.7 mg/kg, 5 mg/kg, and 7.5 mg/kg single doses, respectively. Normal dosage is 15 mg/kg daily, divided into 2-3 equal doses.

Workup

  1. customIn normal adults, average peak serum concentrations of about 12, 16 and 21 μg/ml are obtained about 1 hour after intramuscular administration of 3.7 mg/kg, 5 mg/kg, and 7.5 mg/kg single doses

Sources & evidence

ORD record
ord-6c8aa2c83d8d4cdbb74f04e25ca4e904
Source dataset
uspto-grants-1984_05
Patent number
US04447529

Linked notes

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