5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

HRID 5439

Reaction equation

HRID 5439 reaction equation
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18].CO>CO>[ClH:18].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 152293635-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridineHCID 21893726Hydrochloride methanol

Product 1

HCID 200866555-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochlorideYield 89.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Workup

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from chloroform ether
  3. customThen, the crystals thus obtained
  4. washwere washed with ether
  5. customdried

Sources & evidence

ORD record
ord-90e3544a7e8d48009be88fd306d4e8e7
Source dataset
uspto-grants-1993_09
Patent number
US05244908

Linked notes

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