1,3-Dichloroacetone → 4-(Chloromethyl)-2-(methoxymethyl)-1,3-thiazole
Reaction equation
[CH3:1][O:2][CH2:3][C:4]([NH2:6])=[S:5].[Cl:7][CH2:8][C:9]([CH2:11]Cl)=O>C(O)C>[Cl:7][CH2:8][C:9]1[N:6]=[C:4]([CH2:3][O:2][CH3:1])[S:5][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 9 g of 2-methoxy-thioacetamide and 10.87 g 1,3-dichloroacetone in 90 ml ethanol was refluxed for 2 h. The solvent was evaporated and the residue neutralized with saturated sodium bicarbonate solution. After extraction with ether the organic phase was washed twice with water and dried over sodium sulfate. Evaporation of the solvent left 13.0 g crude product.
Workup
- customThe solvent was evaporated
- extractionAfter extraction with ether the organic phase
- washwas washed twice with water
- dry with materialdried over sodium sulfate
- customEvaporation of the solvent
- waitleft 13.0 g crude product
Sources & evidence
- ORD record
- ord-842d2059ff3b433aacd080f788093fe6
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05622953
Reaction notes
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