3-Hydroxybenzyl alcohol → Benzenemethanol, 3-(2-quinolinylmethoxy)-

HRID 54532

Reaction equation

HRID 54532 reaction equation
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[OH:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][OH:18].OC1C=CC(CO)=CC=1>>[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[CH:12][C:3]=1[CH2:2][O:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][OH:18]

Participants

4

Reactant 3

HCID 1023-Hydroxybenzyl alcoholHCID 1254-Hydroxybenzyl AlcoholHCID 203942-(Chloromethyl)quinoline

Product 1

HCID 14650410Benzenemethanol, 3-(2-quinolinylmethoxy)-Yield 85%

Procedure

The procedure from Example 6, part A was used except 2-(chloromethyl)quinoline was substituted for 7chloro-(2-chloromethyl)quinoline and 3-hydroxybenzyl alcohol was substituted for 4-hydroxybenzyl alcohol. The intermediate was obtained in 85% yield: mp 82°-86° C.

Workup

  1. customThe intermediate was obtained in 85% yield

Sources & evidence

ORD record
ord-dd758f7908b94354828ffdecb5b6978d
Source dataset
uspto-grants-1997_04
Patent number
US05622969

Linked notes

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