HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54545Generated: October 26, 2026
Water → N-[2-[1-tert-butoxycarbonylpiperidin-4-yl]ethyl]phthalimide
https://huagongshe.com/reaction/54545
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | tert-Butyl 4-(2-((methanesulfonyl)oxy)ethyl)piperidine-1-carboxylate | HCID 15229596 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[2-[1-tert-butoxycarbonylpiperidin-4-yl]ethyl]phthalimide | HCID 15851771 | 80% |
Reaction Steps
A mixture of 1-tert-butoxycarbonyl-4-(2-mesyloxyethyl)piperidine (1.20 g) and potassium phthalimide (0.80 g) in N,N-dimethylformamide (15 ml) was stirred at 40° C. for 2 hours. The mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, and dried over magnesium sulfate and evaporated in vacuo to give N-[2-[1-tert-butoxycarbonylpiperidin-4-yl]ethyl]phthalimide (1.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05622976 |
|---|
| Source dataset | uspto-grants-1997_04 |
|---|
| ORD ID | ord-834af114af9340198c258f1eb7345cf9 |
|---|
| Source note | uspto-grants-1997_04 |
|---|
