Hydrazine → HCID 178525216, compound

HRID 547150

Reaction equation

HRID 547150 reaction equation
[NH2:1][NH2:2].[O:3]=[C:4]1[C:8]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][C:6](=O)[O:5]1>C(O)(=O)C>[OH:5][C:6]1[CH:7]=[C:8]([CH2:9][C:10]([OH:12])=[O:11])[C:4](=[O:3])[NH:1][N:2]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 65163Aconitic anhydride

Product 1

HCID 178525216HCID 178525216, compoundYield 80.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

A solution of hydrazine (103 mg, 3.21 mmol) in acetic acid (16 mL) was added to (2,5-dioxo-2,5-dihydro-furan-3-yl)acetic acid (500 mg, 3.04 mmol) under cooling with ice, and the mixture was heated with stirring at an external temperature of 76 to 84° C. for one hour. The reaction mixture was concentrated under reduced pressure. The resulting solid was sequentially washed with water, ethanol and ether to give the title compound (414 mg, 80%).

Workup

  1. temperatureunder cooling with ice
  2. temperaturethe mixture was heated
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. washThe resulting solid was sequentially washed with water, ethanol and ether

Sources & evidence

ORD record
ord-cff7547648714211adb0e715f20ea4c8
Source dataset
uspto-grants-2011_05
Patent number
US07935688B2

Linked notes

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