5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 5481

Reaction equation

HRID 5481 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

Product 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridineYield 99.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

After a suspension of 5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Workup

  1. washwas washed with 3N sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationThen, the solvent was distilled off

Sources & evidence

ORD record
ord-d247e64e0eef42c0ae0a6b34795adbf6
Source dataset
uspto-grants-1993_09
Patent number
US05244908

Linked notes

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