HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetic acid → (7-Methoxy-1-benzofuran-3-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 7-Methoxybenzofuran-3(2H)-one | HCID 2818112 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | (7-Methoxy-1-benzofuran-3-yl)acetonitrile | HCID 15618729 | 30% |
Reaction Steps
The solution of 7-methoxy-1-benzofuran-3(2H)-one (reference) (7.5 g, 0.046 mol), cyanoacetic acid (19.55 g, 0.23 mol) and ammonium acetate (7.08 g, 0.092 mol) in xylene was refluxed for 16-18 h. using dean stark apparatus. Xylene was removed under diminished pressure. Brown black residue was taken in ethyl acetate, washed with water and concentrated. On purification on silica gel it yielded (7-methoxy-1-benzofuran-3-yl)acetonitrile (30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943634B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-ac3f40c2faa7422a8e9aaa0d2bc845a9 |
| Source note | uspto-grants-2011_05 |