2-Bromo-1-(4-fluorophenyl)ethan-1-one → (RS)-2-[2-(4-Fluoro-phenyl)-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl ester

HRID 549338

Reaction equation

HRID 549338 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([OH:17])=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([O:17][CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)=[O:21])=[O:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 50585361-Boc-2-Piperidineacetic Acid

Product 1

HCID 86629009(RS)-2-[2-(4-Fluoro-phenyl)-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl esterYield 96.9%

Procedure

The title compound (3.83 g) was prepared from (RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (2.54 g) and 2-bromo-4′-fluoroacetophenone (2.26 g) according to the method of description 36.

Sources & evidence

ORD record
ord-ed19f1b142ba48d9add7eee3e7e5d608
Source dataset
uspto-grants-2011_05
Patent number
US07943645B2

Linked notes

Loading…