Sulfur → 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Sulfur	HCID 5362487	—
Reactant	3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine	HCID 19957261	—
Solvent	Decalin	HCID 7044	—
Product	2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine	HCID 19957277	49.1%

Reaction Conditions

Temperature	190 °C

Reaction Steps

A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05624931
Source dataset	uspto-grants-1997_04
ORD ID	ord-3ed64ac8d49e4086a99c392c103b6c7c
Source note	uspto-grants-1997_04