5-Phenylthiophene-2-carbaldehyde → 3-Bromo-2-fluoro-6-methyl-1-(5-phenyl-2-thienylmethyl)benzene

HRID 550024

Reaction equation

HRID 550024 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[F:9].[C:10]1([C:16]2[S:20][C:19]([CH:21]=O)=[CH:18][CH:17]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:1][C:2]1[C:3]([F:9])=[C:4]([CH2:21][C:19]2[S:20][C:16]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:17][CH:18]=2)[C:5]([CH3:8])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1770535-Phenylthiophene-2-carbaldehydeHCID 5732804-Bromo-3-fluorotoluene

Product 1

HCID 666085273-Bromo-2-fluoro-6-methyl-1-(5-phenyl-2-thienylmethyl)benzene

Procedure

4-Bromo-3-fluorotoluene and 5-phenyl-2-thiophenecarboxaldehyde were treated in a manner similar to Reference Example 116 to give the target compound as pale blue powders. APCI-Mass m/Z 361/363 (M+H).

Sources & evidence

ORD record
ord-59809dccd2824e33bf09d80dec4dcc27
Source dataset
uspto-grants-2011_05
Patent number
US07943788B2

Linked notes

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